Survivin is an important member of the apoptosis inhibitory protein family, which plays an important role in suppressing apoptosis, promoting proliferation and vascular formation. The occurrence and development of tumors are related to apoptosis and imbalance of proliferation. Gastric cancer is the most common malignant tumor in the digestive system. Due to the inadequate symptoms of early symptoms, most of them have entered the middle and late stages during diagnosis. It is easy to relapse and metastasize. The mortality rate is high, which seriously endangers human health. Research have found that Survivin expresses high in gastric cancer tissue, participating in the proliferation of tumor cells, inhibiting apoptosis and the formation of blood vessels, and is of great significance to the diagnosis, judgment transfer and prognosis evaluation of gastric cancer, especially the value of combined with a number of indicators is greater. Therefore, finding an early diagnosis and judging the ideal tumor logo combination of the early diagnosis and judgment of the prognosis is important. This article reviews the biological characteristics of Survivin and its research progress in gastric cancer, so as to provide theoretical basis for the diagnosis of gastric cancer and new ideas for the successful prevention and treatment of tumors.
| Published in | American Journal of Health Research (Volume 12, Issue 2) |
| DOI | 10.11648/j.ajhr.20241202.12 |
| Page(s) | 25-36 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Apoptosis Inhibiting Protein, Survivin, Gastric Cancer, Prognosis
| [1] | Hou Jianzhang, Li Yong. Relationship Between the Expression of S100P in Gastric Cancer Tissue and Clinical Pathology [J]. American Journal of Clinical and Experimental Medicine, 2021, 9(3): 55-64. https://doi.org/10.11648/j.ajcem.20210903.12 |
| [2] | Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics2020: GLOBO-CAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries [J]. CA Cancer J Clin, 2021, 71 (3): 209-249. https://doi.org/10.3322/caac.21660 |
| [3] | Yan Chao, Shan Fei, Li Ziyu. Analysis of Global Burden of Gastric Cancer in 2020: Focusing on the Statistics in China [J]. China Cancer, 2023, 32 (3): 161-170. https://doi.org/10.11735/j.issn.1004-0242.2023.03.A001 |
| [4] | Sun Kexin, Zheng Rongshou, Zhang Siwei, et al. Report of Cancer Incidence and Mortality in Different Areas of China, 2015 [J]. China Cancer, 2019, 28(1): 1-11. https://doi.org/10.11735/j.issn.1004-0242.2019.01.A001 |
| [5] | Zhang Shuli, Hou Jianzhang, Li Hongyan, et al. Research Progress on Apoptosis Inhibitory Protein Survivin and Its Application in Digestive Tract Tumors [J]. Ameri-can Journal of Health Research, 2023; 11(3): 84-94. https://doi.org/10.11648/j.ajhr.20231103.13 |
| [6] | Ambrosini G, Adida C, Altieri DC. A novel anti-apoptosis gene, Survivin, expressed in cancer and lymphoma [J]. Nat Med, 1997, 3(8): 917-921. https://doi.org/10.1038/nm0897-917 |
| [7] | Ma XY. Survivin, an important regulator of cell division and apoptosis: a target for new anticancer drugs [J]. Chemistry of life, 2010, 30(3): 338-344. |
| [8] | Erridge S, Pucher PH, Markar SR, et al. Meta-analysis of determinants of survival following treatment of recurrent hepatocellular carcinoma [J]. Br J Surg, 2017, 104(11): 1433-1442. https://doi.org/10.1002/bjs.10597 |
| [9] | Gu LH, Zhou RX. Research progress of the relationship between apoptosis inhibitor protein Survivin and gastric cancer [J]. Sichuan J Anat, 2009, 17(4): 19-21. |
| [10] | Chen KY, He HH, Ke JY, et al. Expression of Survivin gene in proliferation and apoptosis of hepatocellular carcinoma cells [J]. Hainan Med J, 2021, 32(4): 409-412. https://doi.org/10.3969/j.issn.1003-6350.2010.04.001 |
| [11] | Zhao Ruijie, Li yinqian, Wang hui, et al. Relationship of Caspase family and apoptosis [J]. Chinese Journal of Animal Science, 2010, 46(17): 73-78. |
| [12] | Stepien A, Izdebska M, Grzanka A. The types of cell death [J]. Postepy Hig Med Dosw (Online), 2007, 61: 420-428. PMID: 17679912. |
| [13] | Van Opdenbosch N, Lamkanfi M. Caspases in Cell Death, Inflammation and Disease [J]. Immunity, 2019, 50(6): 1352-1364. https://doi.org/10.1016/j.immuni.2019.05.020 |
| [14] | Meng J, Dang T. The Effect of CCN1 on the expression of Caspase-2 in Esophageal carcinoma cells [J]. Inner Mongolia Med J, 2022, 54(6): 641-646. https://doi.org/10.16096/J.cnki.nmgyxzz.2022.54.06.001 |
| [15] | Liu XB. Analysis of the correlation between apoptosis related protein Caspase and male condyloma acuminatum [J]. Chinese Journal of Human Sexuality, 2020, 29(11): 134-138. https://doi.org/10.3969 /j.issn.1672-1993.2020.11.040 |
| [16] | Liu D, YU ZX, Zhang HX. Cyanidin-3-o-glucoside inhibits H2O2-induced apoptosis by Mediating the cascaded reaction of caspase [J]. Acta Nutrimenta Sinica, 2020, 42(4): 369-373. https://doi.org/10.13325/j.cnki.acta.nutr.sin.2020.04.008 |
| [17] | Poomsawat Sopee, Punyasingh Jirapa, Vejchapipat Paisarn. Overexpression of Survivin and Caspase 3 in Oral Carcinogenesis [J]. Appl Immunohistochem Mol Morphol, 2014, 22(1): 65-71. https://doi.org/10.1097/PAI.0b013e31828a0d0c |
| [18] | Lin XR, Qian H, Lv JW, et al. Research progress of Caspases family involved in cell apoptosis of dental pulp during the root Absorption of deciduous teeth [J]. Stomatology, 2022, 42(2): 180-183. https://doi.org/10.13591/j.cnki.kqyx.2022.02.017 |
| [19] | Kalkavan H, Green. D R. MOMP, cell suicide as a BCL-2 family business [J]. Cell Death Differ, 2017, 25(1): 1-10. https://doi.org/10.1038/cdd.2017.179 |
| [20] | Mobahat M, Narendran A, Riabowol K. Survivin as a Preferential Target for Cancer Therapy [J]. Int J Mol Sci, 2014, 15, 2494-2516. https://doi.org/10.3390/ijms15022494 |
| [21] | Yiming Zhang, Hai Huang, Huimin Zhou, et al. Activation of Nuclear Factor kB Pathway and Downstream Targets Survivin and Livin by SHARPIN Contributes to the Progression and Metastasis of Prostate Cancer [J]. Cancer, 2017, 123(5): 892-893. https://doi.org/10.1002/cncr.30497 |
| [22] | O’connor DS, Schechner JS, Adida C, et al. Control of Apoptosis during Angiogenesis by Survivin Expression in Endothelial Cells [J]. Am J Pathol, 2000, 156(2): 393-398. https://doi.org/10.1016/S0002-9440(10)64742-6 |
| [23] | Jin Ling, Ding Lina, Yu Shuo, et al. Research progress of apoptosis protein inhibitor Survivin [J]. Chin Lab Diagn, 2018, 22(6): 1100-1102. |
| [24] | Chen HL, Xie CH, Zhong QJ, et al. Effects of Bevacizumab Combined with Chemotherapy on Serum VEGF and bFGF Levels in Patients with Advanced Non-squamous Non-small Cell Lung Cancer [J]. Drug Evaluation, 2022, 19(16): 996-999. https://doi.org/10.19939/j.cnki.1672-2809.2022.16.11 |
| [25] | Li S, Wang L, Meng Y, et al. Increased levels of LAPTM4B, VEGF and survivin are correlated with tumor progression and poor prognosis in breast cancer patients [J]. Oncotarget, 2017, 8(25): 41282-41293. https://doi.org/10.18632/oncotarget.17176 |
| [26] | Lu CD, Ahieri DC, Tanigawa N. Expression of a novel antiapoptosis Gene, Survivin, correlated with tumor cell apoptosis and p53 accumulation in gastric carcinomas [J]. Cancer Res, 1998, 58(9): 1808-1812. PMID: 9581817 |
| [27] | Yu J, Leung WK, Ebert MP, et a1. Increased expression of Survivin in gastric cancer patients and in first degree relatives [J]. Br J Cancer, 2002, 87(1): 91-97. https://doi.org/10.1038/sj.bjc.6600421 |
| [28] | Zhu XD, Lin GJ, Qian LP, et a1. Expression of Survivin in human gastric carcinoma and gastric carcinoma model of rats [J]. World J Gastro Enterol, 2003, 9(7): 1435-1438. https://doi.org/10.3748/wjg.v9.i7.1435 |
| [29] | Song KY, Jung CK, Park WS, et a1. Expression of the Antiapoptosis Gene Survivin Predicts Poor Prognosis of Stage III Gastric Adenocarcinoma [J]. Jpn J Clin Oncol, 2009, 39(5): 290-296. https://doi.org/10.1093/jjco/hyp020 |
| [30] | Da CL, Xin Y, Zhao J, et al. Signiffcance and relationship between Yes-associated protein and Survivin expression in gastric carcinoma and precancerous lesions [J]. World J Gastroenterol 2009, 15(32): 4055-4061. https://doi.org/10.3748/wjg.15.4055 |
| [31] | Yao XQ, Ku FK, Qi xP, et al. Expression of Survivin in human gastric Adenocarcinomas: correlation with proliferation and apoptosis [J]. Zhong hua Wai Ke Za Zhi, 2004, 42(3): 145-148. |
| [32] | Sun Diwen, Chen Qi. Expression of Survivin protein in early gastric cancer and in precancerosis and its clinical significance [J]. Chin J Cancer Prev Treat, 2008, 15(16): 1215-1217. https://doi.org/10.16073/j.cnki.cjcpt.2008.16.028 |
| [33] | Luo Xue, Yao Zhongxiang. Expression and significance of Survivin in gastric carcinoma [J]. Modern medicine and hygiene, 2009, 25(3): 338-339. |
| [34] | Sun Yanxia, Shi Zhangzhen, Lu Zhenxia, et al. The Expression of Survivin gene in gastric cancerous tissue and its clinical significance [J]. Chin J Lab Diagn, 2012, 16(5): 844-846. |
| [35] | Kania J, Konturek SJ, Marliez K, et al. Expression of Survivin and easpase-3 in gastric cancer [J]. Dig Dis Sci, 2003, 48(2): 266-271. https://doi.org/10.1023/a:1021915124064 |
| [36] | Xu Tianxiang, Hu Jiang, Liu Yanheng. Expression of Survivin in gastric cancer and its clinical significance [J]. Inner Mongolia Med J, 2014, 46(10): 1153-1157. https://doi.org/10.16096/j.cnki.nmgyxzz.2014.10.001 |
| [37] | Jiao Jianxin, Wen Fengxia, Zhang Lingling, et al. Relationship bet-ween Survivin expression and Helicobacter pylori infection in gastric cancer [J]. China Modern Medicine, 2016, 23(4): 4-8. |
| [38] | Shintani M, Sangawa A, Yamao N, et al. Immunohistochem ical expression of nuclear and cytoplasmic Survivin in gastrointestinal carcinoma [J]. Int J Clin ExpPathol, 2013, 6(12): 2919-2927. PMID: 24294379 |
| [39] | Jia YF, Hu RF, Li P, et al. DEC1 is required for anti-apoptotic activity of gastric cancer cells under hypoxia by promoting Survivin expression [J] Gastric Cancer, 2018, 21(4): 632-642. https://doi.org/10.1007/s10120-017-0780-z |
| [40] | Abudoureyimu A, Muhemaitibake A. Arsenic trioxide regulates gastric cancer cell apoptosis by mediating cAMP [J]. Eur Rev Med Pharmacol Sci, 2017, 21(3): 612-617. PMID: 28239804 |
| [41] | Fang Yu, Wang Linling, Wang Haijuan, et al. Expression and clinical significance of Survivin and Bcl-2 in gastric carcinoma [J]. Anti-tumor Pharmacy, 2021, 11(4): 474-479. https://doi.org/10.3969/j.issn.2095-1264.2021.04.14 |
| [42] | Li Hong, Hui Qiyuan ‚Tian Zhengliang. Quantitative Analysis of Survivin and CD34in Gastric Carcinoma and Dysplasia and Their Clinical Significance [J]. Cancer prevention and treatment research, 2010, 37(5): 544-546, 550. https://doi.org/10.3971/j.issn.1000-8578.2010.05.015 |
| [43] | Pu Z, Wang Q, Xie H, et al. Clinical pathological and prognostic significance of survivin expression in renal cell carcinoma: a metaanalysis [J]. Oncotarget, 2017, 8(12): 19825-19833. https://doi.org/10.18632/oncotarget.15082 |
| [44] | Lee GH, Joo YE, Koh YS, et al. Expression of Survivin in gastric cancer and its relationship with tumor angiogenesis [J]. Eur J Gastroenterol Hepatol, 2006, 18(9): 957-963. https://doi.org/10.1097/01.meg.0000230086.83792.56 |
| [45] | Li Dongxia, Si Yanli, Deng Xiaohui, et al. Expression of Survivin and Bcl-2 in 52 patients with gastric cancer [J]. Chongqing Medical Science, 2011, 40(22): 2206-2207, 2210. https://doi.org/10.3969/j.issn.1671-8348.2011.22.008 |
| [46] | Wang Songwen, Li Yong, Wang Jie. Expression of Survivin and Metastin in Gastric Carcinoma and its Significance [J]. Journal of Oncolog, 2010, 16(12): 961-964. |
| [47] | Hu Zhongdong, Zhong Meizuo, Zhou Huijun. Expression and significance of MMP-7 and Survivin in gastric cancer [J]. Cancer prevention and treatment research, 2012, 39(11): 1349-1352. https://doi.org/10.3971/j.issn.1000-8578.2012.11.017 |
| [48] | He Hongmei, Xu Aiguo, Sun Xiuhua. Expression of Survivin in gastric cancer and its influence on prognosis [J]. World Latest Medical Information Digest, 2015, 159(36): 18-20. https://doi.org/10.3969/j.issn.1671-3141.2015.36.014 |
| [49] | Sun Yuanshui, Ye ZaiYuan, Zhao ZhongSheng, et al. Expression of vascular endothelial growth factor-C and survivin in gastric carcinoma and their clinical implications [J]. Chin J Gastrointest Surg, 2006, 9(3): 264-267. |
| [50] | Zhou Wei, Dai Qigang, Deng Xing, et al. Expressions of Survivin and Bcl-2 in Gastric Carcinoma and their Significance [J]. Journal ofOncology, 2009, 15(6): 549-551. |
| [51] | Yan Yuping‚Yin Xiangli. Correlation study on expression of survivin and caspase-3with biological behavior in gastric carcinoma [J]. Journal of Clinical Medicine in Practice, 2013, 17 (13): 24-27. https://doi.org/10.7619/jcmp.201313008 |
| [52] | Wang X W. Expression of survivin and caspase-3 in gastric cancer and their correlation with clinicopathological features [J]. Chinese Journal of Gerontology, 2012, 32(20): 4405-4406. https://doi.org/10. 3969/j.issn.1005-9202. 2012.20. 023 |
| [53] | Ying Rongbiao, Feng Jun, Li Jianjun, et al. Expression of survivin and caspase-3 in gastric cancer and its clinical significance [J]. China Oncology, 2010, 20(1): 17-21. |
| [54] | Liu Xiaomin, Li Qiaoyun, Chen Canbin, et al. Expressions and Clinicopathological Significances of PIG11 and Caspase-3 Protein in the Gastric Carcinoma [J] biomed cnjournals.com Progress in Modern Biomedicine, 2018, 18(4): 657-661. https://doi.org/10.13241/j.cnki.pmb.2018.04.012 |
| [55] | Pu Haichao, Wang Chunyan. Analysis of Survivin and Caspase-3 Expression in Gastric Cancer Patients with Different Stages [J]. Smart Healthcare, 2022, 8(7): 65-67. https://doi.org/10.19335/j.cnki.2096-1219.2022.07.021 |
| [56] | Shayimu Paerhati, Yusufu Aikeremu, Tuerdi Rousidan, et al. Expression and Clinical Correlation Analysis of Survivin and PTEN Proteins in Gastric Cancer [J]. The Practical Journal of Cancer, 2020, 35(8): 1253-1257. https://doi.org/10.3969/j.issn.1001-5930.2020.08.009 |
| [57] | Liu Z, Zhang X, Xu X, et al... RUNX3 inhibits Survivin expression and induces cell apoptosis in gastric cancer [J]. Eur J Cell Biol 2014, 93(1): 118-126. https://doi.org/10.1016/j.ejcb.2014.02.002 |
| [58] | Miyachi K, Sasaki K, Onodera S, et al. Correlation between Survivin mRNA expression and lymph node metastasis in gastric cancer [J]. Gastric Cancer, 2003, 6(4): 217-224. https://doi.org/10.1007/s10120-003-0255-2 |
| [59] | Meng H, Lu C, Mabuchi H, et al. Prognostic signiffcance and different properties of Survivin splicing variants in gastric cancer [J]. Cancer Lett 2004, 216(2): 147-155. https://doi.org/10.1016/j.canlet.2003.12.020 |
| [60] | Bertazza L, Mocellin S, Marcher A, et a1. Survivin gene levels in the peripheral blood of patients with gastric cancer independently predict survival [J]. J Transl Med, 2009, 7: 111. https://doi.org/10.1186/1479-5876-7-111 |
| [61] | Deng Jianzhong, Jin Jianhua, Lu Wenbin, et al. The expression of survivin mRNA in the peripheral blood of gastric cancer and its clinical significance [J]. China Oncology, 2010, 20(12): 903-906. |
| [62] | Yie SM, Lou B, Ye SR, et al. Detection of Survivin-Expressing Circulating Cancer Cells (CCCs) in Peripheral Blood of Patients with Gastric and Colorectal Cancer Reveals High Risks of Relapse [J]. Annals of Surgical Oncology, 2008, 15(11): 3073-3082. https://doi.org/10.1245/s10434-008-0069-x |
| [63] | Deng Jianzhong, Jin Jianhua, Lu Wenbin, et al. Relationship between the expression of survivin mRNA in the peripheral blood and gastric carcinoma [J]. Journal of Clinical Medicine in Practice, 2012, 12(5): 99-101. |
| [64] | Liu Jinlong, Wu shuyan, Liu Lihong, et al. Expression of Survivin in the peripheral blood of Patients with Gastric cancer and Its Relationship with Biological Behaviors of Gastric cancer [J]. Clin J Lab Diagn, 2012, 16(1): 57-59. |
| [65] | Chen Jianhua, Liu Jinlong. Diagnostic value of survivin expression in peripheral blood for gastric cancer [J]. Hebei Medicine, 2014, 20(2): 298-300. https://doi.org/10.3969/j.issn.1006-6233.2014. 02.049 |
| [66] | Chen Guofei, Yang Hua, JiangXingxin, et al. Expressions of Survivin mRNA and CK19 mRNA in peripheral blood of patients with gastric cancer and clinical signiffcance [J]. China Journal of Modern Medicine, 2018, 28(7): 55-60. https://doi.org/10.3969/j.issn.1005-8982.2018.07.011 |
| [67] | Bai Yurong, Lu Yidan, Sun Yangcheng, et al. Clinical efficacy of prophylactic hyperthermic intraperitoneal chemotherapy for advanced gastric cancer: a meta-analysis [J]. J Practical Oncology, 2021, 36(4): 306-313. https://doi.org/10.13267/j.cnki.syzlzz.2021.064 |
| [68] | Chae HD. Role of genetic detection in peritoneal washes with gastric carcinoma: The past, present and future [J]. World J Gastrointest Oncol, 2016, 8(3): 289-296. https://doi.org/10.4251/wjgo.v8.i3.289 |
| [69] | Kodera Y, Yamamura Y, Shimizu Y, et al. Peritoneal washing cytology: prognostic value of positive findings in patients with gastric carcinoma undergoing a potentially curative resection [J]. J Surg Oncol. 1999, 72(2): 60-64. https://doi.org/10.1002/(sici)1096-9098(199910)72:2<60::aid-jso3>3.0.co;2-1 |
| [70] | Xiao Y, Zhang J, He X, et al. Diagnostic values of carcinoembryonic antigen in predicting peritoneal recurrence after curative resection of gastric cancer: a meta-analysis [J]. Ir J Med Sci. 2014, 183(4): 557-64. https://doi.org/10.1007/s11845-013-1051-6 |
| [71] | Katsuragi K, Yashiro M, Sawada T, Prognostic impact of PCR-based identification of isolated tumour cells in the peritoneal lavage fluid of gastric cancer patients who underwent a curative R0 resection [J]. Br J Cancer, 2007, 97(4): 550-556. https://doi.org/10.1038/sj.bjc.6603909 |
| [72] | Tan Siyi, Yu Lixia, Wei Jia, et al. Clinical significance of CEA mRNA expression in peritoneal lavage fluid for patients with gastric cancer after radical surgery [J]. Chin J Cancer Biother 2020, 27(5): 541-546. https://doi.org/10.3872/j.issn.1007-385x.2020.05.011 |
| [73] | Wang ZN, Xu HM, Jiang L, et a1. Expression of Survivin mRNA in peritoneal lavage fluid from patients with gastric carcinoma [J]. Chin Med J (Engl), 2004, 117(8): 1210-1217. PMID: 15361297 |
| [74] | Wang Ying, Liang Huan. Expression of serum VEGF, Survivin and p53 in lung cancer and the ircorrelation [J]. Chinese Journal of Health Laboratory Technology, 2008, 18(8): 1573-1575. |
| [75] | Zhai Nailiang, Liu Jinping, Gao Fuquan. Expression of serum VEGF, Ang-2 and Survivin in lung carcinoma and their correlation [J]. BMU J, 2016, 39(1): 23-26. |
| [76] | Huang Yanbo, Xu Wenmin, Hong Zehua, et al. The application value of serum Livin combined with Survivin detection in the diagnosis of retinoblastoma [J]. China Medicine Pharmacy, 2016, 6(11): 144-147. |
| [77] | Zhang Jun, LiuJun. Significance analysis of vascnlar endothelial growth factor and Snrvivinin Patients with gastric carcinoma [J]. Int J Lab Med, 2012, 33(6): 679-680. https://doi.org/10.3969/j.issn.1673-4130.2012.06.027 |
| [78] | Fu Baiyu, LinYi, XUu Qi, et al. Application value of combined detection of serum p53, PDCD-5 and Survivin in gastric cancer [J]. J Mol Diagn Ther, 2021, 13(4): 615-618, 622. https://doi.org/10.19930/j.cnki.jmdt.2021.04.026 |
APA Style
Jianzhang, H., Shuli, Z., Jiyong, L., Hongyan, L., Zhenjiang, H. (2024). Research Progress of Apoptosis Inhibitory Protein Survivin in Gastric Cancer. American Journal of Health Research, 12(2), 25-36. https://doi.org/10.11648/j.ajhr.20241202.12
ACS Style
Jianzhang, H.; Shuli, Z.; Jiyong, L.; Hongyan, L.; Zhenjiang, H. Research Progress of Apoptosis Inhibitory Protein Survivin in Gastric Cancer. Am. J. Health Res. 2024, 12(2), 25-36. doi: 10.11648/j.ajhr.20241202.12
AMA Style
Jianzhang H, Shuli Z, Jiyong L, Hongyan L, Zhenjiang H. Research Progress of Apoptosis Inhibitory Protein Survivin in Gastric Cancer. Am J Health Res. 2024;12(2):25-36. doi: 10.11648/j.ajhr.20241202.12
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Download@article{10.11648/j.ajhr.20241202.12,
author = {Hou Jianzhang and Zhang Shuli and Li Jiyong and Li Hongyan and Hou Zhenjiang},
title = {Research Progress of Apoptosis Inhibitory Protein Survivin in Gastric Cancer},
journal = {American Journal of Health Research},
volume = {12},
number = {2},
pages = {25-36},
doi = {10.11648/j.ajhr.20241202.12},
url = {https://doi.org/10.11648/j.ajhr.20241202.12},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajhr.20241202.12},
abstract = {Survivin is an important member of the apoptosis inhibitory protein family, which plays an important role in suppressing apoptosis, promoting proliferation and vascular formation. The occurrence and development of tumors are related to apoptosis and imbalance of proliferation. Gastric cancer is the most common malignant tumor in the digestive system. Due to the inadequate symptoms of early symptoms, most of them have entered the middle and late stages during diagnosis. It is easy to relapse and metastasize. The mortality rate is high, which seriously endangers human health. Research have found that Survivin expresses high in gastric cancer tissue, participating in the proliferation of tumor cells, inhibiting apoptosis and the formation of blood vessels, and is of great significance to the diagnosis, judgment transfer and prognosis evaluation of gastric cancer, especially the value of combined with a number of indicators is greater. Therefore, finding an early diagnosis and judging the ideal tumor logo combination of the early diagnosis and judgment of the prognosis is important. This article reviews the biological characteristics of Survivin and its research progress in gastric cancer, so as to provide theoretical basis for the diagnosis of gastric cancer and new ideas for the successful prevention and treatment of tumors.
},
year = {2024}
}
TY - JOUR T1 - Research Progress of Apoptosis Inhibitory Protein Survivin in Gastric Cancer AU - Hou Jianzhang AU - Zhang Shuli AU - Li Jiyong AU - Li Hongyan AU - Hou Zhenjiang Y1 - 2024/03/25 PY - 2024 N1 - https://doi.org/10.11648/j.ajhr.20241202.12 DO - 10.11648/j.ajhr.20241202.12 T2 - American Journal of Health Research JF - American Journal of Health Research JO - American Journal of Health Research SP - 25 EP - 36 PB - Science Publishing Group SN - 2330-8796 UR - https://doi.org/10.11648/j.ajhr.20241202.12 AB - Survivin is an important member of the apoptosis inhibitory protein family, which plays an important role in suppressing apoptosis, promoting proliferation and vascular formation. The occurrence and development of tumors are related to apoptosis and imbalance of proliferation. Gastric cancer is the most common malignant tumor in the digestive system. Due to the inadequate symptoms of early symptoms, most of them have entered the middle and late stages during diagnosis. It is easy to relapse and metastasize. The mortality rate is high, which seriously endangers human health. Research have found that Survivin expresses high in gastric cancer tissue, participating in the proliferation of tumor cells, inhibiting apoptosis and the formation of blood vessels, and is of great significance to the diagnosis, judgment transfer and prognosis evaluation of gastric cancer, especially the value of combined with a number of indicators is greater. Therefore, finding an early diagnosis and judging the ideal tumor logo combination of the early diagnosis and judgment of the prognosis is important. This article reviews the biological characteristics of Survivin and its research progress in gastric cancer, so as to provide theoretical basis for the diagnosis of gastric cancer and new ideas for the successful prevention and treatment of tumors. VL - 12 IS - 2 ER -
Hepatobiliary Pancreatic (Minimally Invasive) Surgery, Cancer District of Cangzhou People's Hospital, Cangzhou, China
Department of Medical Technology, Cangzhou Medical College, Cangzhou, China
